Ontology highlight
ABSTRACT:
SUBMITTER: Lipatova Z
PROVIDER: S-EPMC3344974 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Lipatova Zhanna Z Belogortseva Natalia N Zhang Xiu Qi XQ Kim Jane J Taussig David D Segev Nava N
Proceedings of the National Academy of Sciences of the United States of America 20120416 18
The key regulators of intracellular trafficking, Ypt/Rab GTPases, are stimulated by specific upstream activators and, when activated, recruit specific downstream effectors to mediate membrane-transport events. The yeast Ypt1 and its human functional homolog hRab1 regulate both endoplasmic reticulum (ER)-to-Golgi transport and autophagy. However, it is not clear whether the mechanism by which these GTPases regulate autophagy depends on their well-documented function in ER-to-Golgi transport. Here ...[more]