Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC3345000 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ye Jiangbin J Mancuso Anthony A Tong Xuemei X Ward Patrick S PS Fan Jing J Rabinowitz Joshua D JD Thompson Craig B CB
Proceedings of the National Academy of Sciences of the United States of America 20120416 18
Despite the fact that most cancer cells display high glycolytic activity, cancer cells selectively express the less active M2 isoform of pyruvate kinase (PKM2). Here we demonstrate that PKM2 expression makes a critical regulatory contribution to the serine synthetic pathway. In the absence of serine, an allosteric activator of PKM2, glycolytic efflux to lactate is significantly reduced in PKM2-expressing cells. This inhibition of PKM2 results in the accumulation of glycolytic intermediates that ...[more]