Ontology highlight
ABSTRACT:
SUBMITTER: Nunnery JK
PROVIDER: S-EPMC3345101 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Nunnery Joshawna K JK Engene Niclas N Byrum Tara T Cao Zhengyu Z Jabba Sairam V SV Pereira Alban R AR Matainaho Teatulohi T Murray Thomas F TF Gerwick William H WH
The Journal of organic chemistry 20120419 9
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neu ...[more]