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Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.


ABSTRACT: Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.

SUBMITTER: Nunnery JK 

PROVIDER: S-EPMC3345101 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.

Nunnery Joshawna K JK   Engene Niclas N   Byrum Tara T   Cao Zhengyu Z   Jabba Sairam V SV   Pereira Alban R AR   Matainaho Teatulohi T   Murray Thomas F TF   Gerwick William H WH  

The Journal of organic chemistry 20120419 9


Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neu  ...[more]

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