Ontology highlight
ABSTRACT:
SUBMITTER: Yesilyurt V
PROVIDER: S-EPMC3345162 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Yesilyurt Volkan V Ramireddy Rajasekharreddy R Azagarsamy Malar A MA Thayumanavan S S
Chemistry (Weinheim an der Bergstrasse, Germany) 20111130 1
Supramolecular nanoassemblies that respond to the presence of proteins are of great interest, as aberrations in protein concentrations represent the primary imbalances found in a diseased state. We present here a molecular design, syntheses, and study of facially amphiphilic dendrimers that respond to the presence of the protein, immunoglobulin G. It is of particular interest that the ligand functionality, utilized for causing the binding-induced disassembly, be lipophilic. Demonstration of bind ...[more]