A resource for the conditional ablation of microRNAs in the mouse.
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ABSTRACT:
SUBMITTER: Park CY
PROVIDER: S-EPMC3345170 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
A resource for the conditional ablation of microRNAs in the mouse.
Park Chong Yon CY Jeker Lukas T LT Carver-Moore Karen K Oh Alyssia A Liu Huey Jiin HJ Cameron Rachel R Richards Hunter H Li Zhongmei Z Adler David D Yoshinaga Yuko Y Martinez Maria M Nefadov Michael M Abbas Abul K AK Weiss Art A Lanier Lewis L LL de Jong Pieter J PJ Bluestone Jeffrey A JA Srivastava Deepak D McManus Michael T MT
Cell reports 20120401 4
The importance of miRNAs during development and disease processes is well established. However, most studies have been done in cells or with patient tissues, and therefore the physiological roles of miRNAs are not well understood. To unravel in vivo functions of miRNAs, we have generated conditional, reporter-tagged knockout-first mice for numerous evolutionarily conserved miRNAs. Here, we report the generation of 162 miRNA targeting vectors, 64 targeted ES cell lines, and 46 germline-transmitte ...[more]
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