Immunologic correlates of the abscopal effect in a patient with melanoma.
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ABSTRACT:
SUBMITTER: Postow MA
PROVIDER: S-EPMC3345206 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
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Immunologic correlates of the abscopal effect in a patient with melanoma.
Postow Michael A MA Callahan Margaret K MK Barker Christopher A CA Yamada Yoshiya Y Yuan Jianda J Kitano Shigehisa S Mu Zhenyu Z Rasalan Teresa T Adamow Matthew M Ritter Erika E Sedrak Christine C Jungbluth Achim A AA Chua Ramon R Yang Arvin S AS Roman Ruth-Ann RA Rosner Samuel S Benson Brenna B Allison James P JP Lesokhin Alexander M AM Gnjatic Sacha S Wolchok Jedd D JD
The New England journal of medicine 20120301 10
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associati ...[more]
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