Dataset Information

Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

ABSTRACT: We previously reported a novelty P3 reduction in depressed patients compared to healthy controls (n=20 per group) in a novelty oddball task using a 31-channel montage. In an independent replication and extension using a 67-channel montage (n=49 per group), reference-free current source density (CSD) waveforms were simplified and quantified by a temporal, covariance-based principal components analysis (PCA) (unrestricted Varimax rotation), yielding factor solutions consistent with other oddball tasks. A factor with a loadings peak at 343 ms summarized the target P3b source as well as a secondary midline frontocentral source for novels and targets. An earlier novelty vertex source (NVS) at 241 ms was present for novels, but not targets, and was reduced in patients. Compatible CSD-PCA findings were also confirmed for the original low-density sample. Results are consistent with a reduced novelty response in clinical depression, involving the early phase of the frontocentral novelty P3.

SUBMITTER: Tenke CE

PROVIDER: S-EPMC3345565 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

Tenke Craig E CE Kayser Jürgen J Stewart Jonathan W JW Bruder Gerard E GE

Psychophysiology 20090915 1

We previously reported a novelty P3 reduction in depressed patients compared to healthy controls (n=20 per group) in a novelty oddball task using a 31-channel montage. In an independent replication and extension using a 67-channel montage (n=49 per group), reference-free current source density (CSD) waveforms were simplified and quantified by a temporal, covariance-based principal components analysis (PCA) (unrestricted Varimax rotation), yielding factor solutions consistent with other oddball t ...[more]

PMID: 19761526

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Project description:We previously reported a preserved 'old-new effect' (enhanced parietal positivity 300-800 ms following correctly-recognized repeated words) in schizophrenia over mid-parietal sites using 31-channel nose-referenced event-related potentials (ERP) and reference-free current source densities (CSD). However, patients showed poorer word recognition memory and reduced left lateral-parietal P3 sources. The present study investigated whether these abnormalities are specific to words. High-density ERPs (67 channels) were recorded from 57 schizophrenic (24 females) and 44 healthy (26 females) right-handed adults during parallel visual continuous recognition memory tasks using common words or unknown faces. To identify and measure neuronal generator patterns underlying ERPs, unrestricted Varimax-PCA was performed using CSD estimates (spherical spline surface Laplacian). Two late source factors peaking at 442 ms (lateral parietal maximum) and 723 ms (centroparietal maximum) accounted for most of the variance between 250 and 850 ms. Poorer (76.6+/-20.0% vs. 85.7+/-12.4% correct) and slower (824+/-170 vs. 755+/-147 ms) performance in patients was accompanied by reduced stimulus-locked parietal sources. However, both controls and patients showed mid-frontal (442 ms) and left parietal (723 ms) old/new effects in both tasks. Whereas mid-frontal old/new effects were comparable across groups and tasks, later left parietal old/new effects were markedly reduced in patients over lateral temporoparietal but not mid-parietal sites, particularly for words, implicating impaired phonological processing. In agreement with prior results, ERP correlates of recognition memory deficits in schizophrenia suggest functional impairments of lateral posterior cortex (stimulus representation) associated with conscious recollection. This deficit was more pronounced for common words despite a greater difficulty to recall unknown faces, indicating that it is not due to a generalized cognitive deficit in schizophrenia.

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Dataset Information

Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

Publications

Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

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