Tooth dentin defects reflect genetic disorders affecting bone mineralization.
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ABSTRACT:
SUBMITTER: Opsahl Vital S
PROVIDER: S-EPMC3345892 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
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Tooth dentin defects reflect genetic disorders affecting bone mineralization.
Opsahl Vital S S Gaucher C C Bardet C C Rowe P S PS George A A Linglart A A Chaussain C C
Bone 20120126 4
Several genetic disorders affecting bone mineralization may manifest during dentin mineralization. Dentin and bone are similar in several aspects, especially pertaining to the composition of the extracellular matrix (ECM) which is secreted by well-differentiated odontoblasts and osteoblasts, respectively. However, unlike bone, dentin is not remodelled and is not involved in the regulation of calcium and phosphate metabolism. In contrast to bone, teeth are accessible tissues with the shedding of ...[more]
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