Ontology highlight
ABSTRACT:
SUBMITTER: Katakam PV
PROVIDER: S-EPMC3345912 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Katakam Prasad V G PV Snipes James A JA Steed Mesia M MM Busija David W DW
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120111 5
Hyperinsulinemia accompanying insulin resistance (IR) is an independent risk factor for stroke. The objective is to examine the cerebrovascular actions of insulin in Zucker obese (ZO) rats with IR and Zucker lean (ZL) control rats. Diameter measurements of cerebral arteries showed diminished insulin-induced vasodilation in ZO compared with ZL. Endothelial denudation revealed vasoconstriction to insulin that was greater in ZO compared with ZL. Nonspecific inhibition of nitric oxide synthase (NOS) ...[more]