Ontology highlight
ABSTRACT:
SUBMITTER: Maguire CA
PROVIDER: S-EPMC3345986 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Maguire Casey A CA Balaj Leonora L Sivaraman Sarada S Crommentuijn Matheus H W MH Ericsson Maria M Mincheva-Nilsson Lucia L Baranov Vladimir V Gianni Davide D Tannous Bakhos A BA Sena-Esteves Miguel M Breakefield Xandra O XO Skog Johan J
Molecular therapy : the journal of the American Society of Gene Therapy 20120207 5
Adeno-associated virus (AAV) vectors have shown remarkable efficiency for gene delivery to cultured cells and in animal models of human disease. However, limitations to AAV vectored gene transfer exist after intravenous transfer, including off-target gene delivery (e.g., liver) and low transduction of target tissue. Here, we show that during production, a fraction of AAV vectors are associated with microvesicles/exosomes, termed vexosomes (vector-exosomes). AAV capsids associated with the surfac ...[more]