Ontology highlight
ABSTRACT:
SUBMITTER: Creze C
PROVIDER: S-EPMC3346078 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120319 19
Pyrococcus abyssi NucS is the founding member of a new family of structure-specific DNA endonucleases that interact with the replication clamp proliferating cell nuclear antigen (PCNA). Using a combination of small angle x-ray scattering and surface plasmon resonance analyses, we demonstrate the formation of a stable complex in solution, in which one molecule of the PabNucS homodimer binds to the outside surface of the PabPCNA homotrimer. Using fluorescent labels, PCNA is shown to increase the b ...[more]