Ontology highlight
ABSTRACT:
SUBMITTER: Itagaki K
PROVIDER: S-EPMC3346144 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Itagaki Keisuke K Naito Toshihiko T Iwakiri Ryota R Haga Makoto M Miura Shougo S Saito Yohei Y Owaki Toshiyuki T Kamiya Sadahiro S Iyoda Takuya T Yajima Hirofumi H Iwashita Shintaro S Ejiri Shin-ichiro S Fukai Fumio F
The Journal of biological chemistry 20120307 19
Anoikis, apoptosis because of loss of cell anchorage, is crucial for tissue homeostasis. Fibronectin not only provides a scaffold for cell anchorage but also harbors a cryptic antiadhesive site capable of inducing β1-integrin inactivation. In this study, this cryptic antiadhesive site is implicated in spontaneous induction of anoikis. Nontransformed fibroblasts (NIH3T3) adhering to a fibronectin substratum underwent anoikis during serum starvation culture. This anoikis was caused by proteolytic ...[more]