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False-negative hepatitis B virus (HBV) surface antigen in a vaccinated dialysis patient with a high level of HBV DNA in the United States.


ABSTRACT: Screening with hepatitis B surface antigen (HBsAg) is highly recommended for at-risk individuals. Mutations in the HBsAg can result in an inability to detect the virus during routine screening. We describe a hemodialysis patient found to have high levels of hepatitis B virus (HBV) DNA and HBV antibody but negative HBsAg on two routine assays.

SUBMITTER: Foy MC 

PROVIDER: S-EPMC3346338 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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False-negative hepatitis B virus (HBV) surface antigen in a vaccinated dialysis patient with a high level of HBV DNA in the United States.

Foy Matthew C MC   Thio Chloe L CL   Hwang Hyon S HS   Saulynas Melissa M   Hamilton James P JP   Fine Derek M DM   Atta Mohamed G MG  

Clinical and vaccine immunology : CVI 20120321 5


Screening with hepatitis B surface antigen (HBsAg) is highly recommended for at-risk individuals. Mutations in the HBsAg can result in an inability to detect the virus during routine screening. We describe a hemodialysis patient found to have high levels of hepatitis B virus (HBV) DNA and HBV antibody but negative HBsAg on two routine assays. ...[more]

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