Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3346750 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Zhang Xiang X Cheng Wei W Listgarten Jennifer J Kadie Carl C Huang Shunping S Wang Wei W Heckerman David D
PloS one 20120507 5
Understanding the organization and function of transcriptional regulatory networks by analyzing high-throughput gene expression profiles is a key problem in computational biology. The challenges in this work are 1) the lack of complete knowledge of the regulatory relationship between the regulators and the associated genes, 2) the potential for spurious associations due to confounding factors, and 3) the number of parameters to learn is usually larger than the number of available microarray expe ...[more]