Evolving sensitivity balances Boolean Networks.
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ABSTRACT:
SUBMITTER: Luo JX
PROVIDER: S-EPMC3346810 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Evolving sensitivity balances Boolean Networks.
Luo Jamie X JX Turner Matthew S MS
PloS one 20120507 5
We investigate the sensitivity of Boolean Networks (BNs) to mutations. We are interested in Boolean Networks as a model of Gene Regulatory Networks (GRNs). We adopt Ribeiro and Kauffman's Ergodic Set and use it to study the long term dynamics of a BN. We define the sensitivity of a BN to be the mean change in its Ergodic Set structure under all possible loss of interaction mutations. In silico experiments were used to selectively evolve BNs for sensitivity to losing interactions. We find that ma ...[more]
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