Ontology highlight
ABSTRACT:
SUBMITTER: Das S
PROVIDER: S-EPMC3347061 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Journal of bacteriology 20120302 9
Bacterial SecA proteins can be categorized by the presence or absence of a variable subdomain (VAR) located within nucleotide-binding domain II of the SecA DEAD motor. Here we show that VAR is dispensable for SecA function, since the VAR deletion mutant secAΔ519-547 displayed a wild-type rate of cellular growth and protein export. Loss or gain of VAR is extremely rare in the history of bacterial evolution, indicating that it appears to contribute to secA function within the relevant species in t ...[more]