Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes.
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ABSTRACT:
SUBMITTER: Hai R
PROVIDER: S-EPMC3347257 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes.
Hai Rong R Krammer Florian F Tan Gene S GS Pica Natalie N Eggink Dirk D Maamary Jad J Margine Irina I Albrecht Randy A RA Palese Peter P
Journal of virology 20120307 10
The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wild-type inf ...[more]
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