Ontology highlight
ABSTRACT:
SUBMITTER: Huang P
PROVIDER: S-EPMC3347384 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Huang Pengwei P Xia Ming M Tan Ming M Zhong Weiming W Wei Chao C Wang Leyi L Morrow Ardythe A Jiang Xi X
Journal of virology 20120215 9
Rotaviruses (RVs), an important cause of severe diarrhea in children, have been found to recognize sialic acid as receptors for host cell attachment. While a few animal RVs (of P[1], P[2], P[3], and P[7]) are sialidase sensitive, human RVs and the majority of animal RVs are sialidase insensitive. In this study, we demonstrated that the surface spike protein VP8* of the major P genotypes of human RVs interacts with the secretor histo-blood group antigens (HBGAs). Strains of the P[4] and P[8] geno ...[more]