Unknown

Dataset Information

0

Association of cytokine gene alleles with the inflammation of human periodontal tissue.

ABSTRACT: Gingivitis and periodontitis are chronic inflammatory diseases of the periodontal tissue in humans caused by both environmental and genetic factors. The human cytokine genes that regulate the immune response may play an important role in the development of these chronic inflammatory diseases. The aim of this study is to analyze the allele status of eight human cytokine genes and to associate it with the inflammation of periodontal tissue in humans. A total of 296 unrelated males of Russian origin were studied. A significant association of theIL1BandIL6 minor alleles and gingivitis was found. In addition, we found a significant association of the OHI-S index with theIL18gene alleles. The influence of genetic factors on gingivitis may contribute to the understanding of the mechanisms of interaction between genetic and environmental factors in periodontal conditions, and to the identification of risk groups for effective prevention and treatment.

SUBMITTER: Safonova AV 

PROVIDER: S-EPMC3347598 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Association of cytokine gene alleles with the inflammation of human periodontal tissue.

Safonova A V AV   Petrin A N AN   Arutyunov S D SD   Tsarev V N VN   Akulenko L A LA   Zorina A O AO   Rebrikov D V DV   Rubanovich A V AV   Borinskaya S A SA   Yankovsky N K NK  

Acta naturae 20110101 1

Gingivitis and periodontitis are chronic inflammatory diseases of the periodontal tissue in humans caused by both environmental and genetic factors. The human cytokine genes that regulate the immune response may play an important role in the development of these chronic inflammatory diseases. The aim of this study is to analyze the allele status of eight human cytokine genes and to associate it with the inflammation of periodontal tissue in humans. A total of 296 unrelated males of Russian origi  ...[more]

Similar Datasets

Unknown Association between Periodontal Health Status and Cognitive Abilities. The Role of Cytokine Profile and Systemic Inflammation.
| S-EPMC5676025 | biostudies-other
Unknown Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue.
| S-EPMC10042704 | biostudies-literature
Unknown The profiling and analysis of gene expression in human periodontal ligament tissue and fibroblasts.
| S-EPMC9209801 | biostudies-literature
Unknown Periodontal bacterial supernatants modify differentiation, migration and inflammatory cytokine expression in human periodontal ligament stem cells.
| S-EPMC6609032 | biostudies-literature
Unknown Calcitonin gene-related peptide regulates periodontal tissue regeneration.
| S-EPMC10791604 | biostudies-literature
Transcriptomics Gene expression analysis of human permanent periodontal ligament tissue
2018-12-31 | GSE75695 | GEO
Unknown A biochemical analysis of human periodontal tissue proteoglycans.
| S-EPMC1132726 | biostudies-other
Unknown Inflammation-related cytokine gene polymorphisms in Behcet's disease.
| S-EPMC4592046 | biostudies-literature
Unknown Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue.
| S-EPMC4526652 | biostudies-literature
Unknown Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies.
| S-EPMC3319933 | biostudies-literature