Transcription Factor DLX5 As a New Target for Promising Antitumor Agents.
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ABSTRACT:
SUBMITTER: Timakhov RA
PROVIDER: S-EPMC3347611 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Transcription Factor DLX5 As a New Target for Promising Antitumor Agents.
Timakhov R A RA Fedichev P O PO Vinnik A A AA Testa J R JR Favorova O O OO
Acta naturae 20110701 3
The crystal structure of the human transcription factor DLX5 has been used for the screening of a library consisting of 10(6 )compounds by the molecular docking technique.In vitro testsof the 14 top-rated ligands showed that compound Q12 displays the best ability to inhibit the proliferation ofDlx5 positive mouse lymphoma cells, which correlates with the down-regulation ofc-mycexpression. Compound Q12 has low toxicity on normal human ovarian epithelial cells and mouse lymphoma cells with absent ...[more]
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