Ontology highlight
ABSTRACT:
SUBMITTER: Cohen ED
PROVIDER: S-EPMC3347685 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cohen Ethan David ED Miller Mayumi F MF Wang Zichao Z Moon Randall T RT Morrisey Edward E EE
Development (Cambridge, England) 20120601 11
Wnt/β-catenin has a biphasic effect on cardiogenesis, promoting the induction of cardiac progenitors but later inhibiting their differentiation. Second heart field progenitors and expression of the second heart field transcription factor Islet1 are inhibited by the loss of β-catenin, indicating that Wnt/β-catenin signaling is necessary for second heart field development. However, expressing a constitutively active β-catenin with Islet1-Cre also inhibits endogenous Islet1 expression, reflecting t ...[more]