Ontology highlight
ABSTRACT:
SUBMITTER: Posfai E
PROVIDER: S-EPMC3347790 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Posfai Eszter E Kunzmann Rico R Brochard Vincent V Salvaing Juliette J Cabuy Erik E Roloff Tim C TC Liu Zichuan Z Tardat Mathieu M van Lohuizen Maarten M Vidal Miguel M Beaujean Nathalie N Peters Antoine H F M AH
Genes & development 20120412 9
In mammals, totipotent embryos are formed by fusion of highly differentiated gametes. Acquisition of totipotency concurs with chromatin remodeling of parental genomes, changes in the maternal transcriptome and proteome, and zygotic genome activation (ZGA). The inefficiency of reprogramming somatic nuclei in reproductive cloning suggests that intergenerational inheritance of germline chromatin contributes to developmental proficiency after natural conception. Here we show that Ring1 and Rnf2, com ...[more]