A molecular wound response program associated with regeneration initiation in planarians.

ABSTRACT: Planarians are capable of regenerating any missing body part and present an attractive system for molecular investigation of regeneration initiation. The gene activation program that occurs at planarian wounds to coordinate regenerative responses remains unknown. We identified a large set of wound-induced genes during regeneration initiation in planarians. Two waves of wound-induced gene expression occurred in differentiated tissues. The first wave includes conserved immediate early genes. Many second-wave genes encode conserved patterning factors required for proper regeneration. Genes of both classes were generally induced by wounding, indicating that a common initial gene expression program is triggered regardless of missing tissue identity. Planarian regeneration uses a population of r

SUBMITTER: Wenemoser D 

PROVIDER: S-EPMC3347795 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature