Ontology highlight
ABSTRACT:
SUBMITTER: Hwang S
PROVIDER: S-EPMC3348177 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Hwang Seungmin S Maloney Nicole S NS Bruinsma Monique W MW Goel Gautam G Duan Erning E Zhang Lei L Shrestha Bimmi B Diamond Michael S MS Dani Adish A Sosnovtsev Stanislav V SV Green Kim Y KY Lopez-Otin Carlos C Xavier Ramnik J RJ Thackray Larissa B LB Virgin Herbert W HW
Cell host & microbe 20120401 4
Host resistance to viral infection requires type I (α/β) and II (γ) interferon (IFN) production. Another important defense mechanism is the degradative activity of macroautophagy (herein autophagy), mediated by the coordinated action of evolutionarily conserved autophagy proteins (Atg). We show that the Atg5-Atg12/Atg16L1 protein complex, whose prior known function is in autophagosome formation, is required for IFNγ-mediated host defense against murine norovirus (MNV) infection. Importantly, the ...[more]