Ontology highlight
ABSTRACT:
SUBMITTER: Qin J
PROVIDER: S-EPMC3348510 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Qin Jichao J Liu Xin X Laffin Brian B Chen Xin X Choy Grace G Jeter Collene R CR Calhoun-Davis Tammy T Li Hangwen H Palapattu Ganesh S GS Pang Shen S Lin Kevin K Huang Jiaoti J Ivanov Ivan I Li Wei W Suraneni Mahipal V MV Tang Dean G DG
Cell stem cell 20120501 5
Prostate cancer (PCa) is heterogeneous and contains both differentiated and undifferentiated tumor cells, but the relative functional contribution of these two cell populations remains unclear. Here we report distinct molecular, cellular, and tumor-propagating properties of PCa cells that express high (PSA(+)) and low (PSA(-/lo)) levels of the differentiation marker PSA. PSA(-/lo) PCa cells are quiescent and refractory to stresses including androgen deprivation, exhibit high clonogenic potential ...[more]