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MageComet--web application for harmonizing existing large-scale experiment descriptions.


ABSTRACT: Meta-analysis of large gene expression datasets obtained from public repositories requires consistently annotated data. Curation of such experiments, however, is an expert activity which involves repetitive manipulation of text. Existing tools for automated curation are few, which bottleneck the analysis pipeline.We present MageComet, a web application for biologists and annotators that facilitates the re-annotation of gene expression experiments in MAGE-TAB format. It incorporates data mining, automatic annotation, use of ontologies and data validation to improve the consistency and quality of experimental meta-data from the ArrayExpress Repository.

SUBMITTER: Xue V 

PROVIDER: S-EPMC3348561 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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MageComet--web application for harmonizing existing large-scale experiment descriptions.

Xue Vincent V   Burdett Tony T   Lukk Margus M   Taylor Julie J   Brazma Alvis A   Parkinson Helen H  

Bioinformatics (Oxford, England) 20120402 10


<h4>Motivation</h4>Meta-analysis of large gene expression datasets obtained from public repositories requires consistently annotated data. Curation of such experiments, however, is an expert activity which involves repetitive manipulation of text. Existing tools for automated curation are few, which bottleneck the analysis pipeline.<h4>Results</h4>We present MageComet, a web application for biologists and annotators that facilitates the re-annotation of gene expression experiments in MAGE-TAB fo  ...[more]

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