Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC3349003 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Liu Fangjun F Porter Ryan M RM Wells James J Glatt Vaida V Pilapil Carmencita C Evans Christopher H CH
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20111228 7
Large, osseous, segmental defects heal poorly. Muscle has a propensity to form bone when exposed to an osteogenic stimulus such as that provided by transfer and expression of cDNA encoding bone morphogenetic protein-2 (BMP-2). The present study evaluated the ability of genetically modified, autologous muscle to heal large cranial defects in rats. Autologous grafts (8 mm × 2 mm) were punched from the biceps femoris muscle and transduced intraoperatively with recombinant adenovirus vector containi ...[more]