Ontology highlight
ABSTRACT:
SUBMITTER: Pane LS
PROVIDER: S-EPMC3349424 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Pane Luna Simona LS Zhang Zhen Z Ferrentino Rosa R Huynh Tuong T Cutillo Luisa L Baldini Antonio A
Human molecular genetics 20120224 11
The developmental role of the T-box transcription factor Tbx1 is exquisitely dosage-sensitive. In this study, we performed a microarray-based transcriptome analysis of E9.5 embryo tissues across a previously generated Tbx1 mouse allelic series. This analysis identified several genes whose expression was affected by Tbx1 dosage. Interestingly, we found that the expression of the gene encoding the cardiogenic transcription factor Mef2c was negatively correlated to Tbx1 dosage. In vivo data reveale ...[more]