Ontology highlight
ABSTRACT:
SUBMITTER: Vitale M
PROVIDER: S-EPMC3350990 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Vitale Monica M Renzone Giovanni G Matsuda Shuji S Scaloni Andrea A D'Adamio Luciano L D'Adamio Luciano L Zambrano Nicola N
Journal of biomedicine & biotechnology 20120426
A dominant mutation in the ITM2B/BRI2 gene causes familial Danish dementia (FDD) in humans. To model FDD in animal systems, a knock-in approach was recently implemented in mice expressing a wild-type and mutant allele, which bears the FDD-associated mutation. Since these FDD(KI) mice show behavioural alterations and impaired synaptic function, we characterized their synaptosomal proteome via two-dimensional differential in-gel electrophoresis. After identification by nanoliquid chromatography co ...[more]