Ontology highlight
ABSTRACT:
SUBMITTER: Vacic V
PROVIDER: S-EPMC3351382 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Vacic Vladimir V McCarthy Shane S Malhotra Dheeraj D Murray Fiona F Chou Hsun-Hua HH Peoples Aine A Makarov Vladimir V Yoon Seungtai S Bhandari Abhishek A Corominas Roser R Iakoucheva Lilia M LM Krastoshevsky Olga O Krause Verena V Larach-Walters Verónica V Welsh David K DK Craig David D Kelsoe John R JR Gershon Elliot S ES Leal Suzanne M SM Dell Aquila Marie M Morris Derek W DW Gill Michael M Corvin Aiden A Insel Paul A PA McClellan Jon J King Mary-Claire MC Karayiorgou Maria M Levy Deborah L DL DeLisi Lynn E LE Sebat Jonathan J
Nature 20110223 7339
Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large (>500-kilobase) CNVs at several loci, including microdeletions at 1q21.1 (ref. 2), 3q29 (ref. 3), 15q13.3 (ref. 2) and 22q11.2 (ref. 4) and microduplication at 16p11.2 (ref. 5). However, these CNVs collectively account for a small fraction (2-4%) of cases, and the relevant genes and neurobiological mechanisms are n ...[more]