Ontology highlight
ABSTRACT:
SUBMITTER: Faust D
PROVIDER: S-EPMC3352310 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Faust Dagmar D Schmitt Christina C Oesch Franz F Oesch-Bartlomowicz Barbara B Schreck Ilona I Weiss Carsten C Dietrich Cornelia C
Cell communication and signaling : CCS 20120309
p38 MAP kinase is known to be activated by cellular stress finally leading to cell cycle arrest or apoptosis. Furthermore, a tumour suppressor role of p38 MAPK has been proposed. In contrast, a requirement of p38 for proliferation has also been described. To clarify this paradox, we investigated stress- and mitogen-induced p38 signalling in the same cell type using fibroblasts. We demonstrate that - in the same cell line - p38 is activated by mitogens or cellular stress, but p38-dependent signal ...[more]