Ontology highlight
ABSTRACT:
SUBMITTER: French DM
PROVIDER: S-EPMC3352934 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
French Dorothy M DM Lin Benjamin C BC Wang Manping M Adams Camellia C Shek Theresa T Hötzel Kathy K Bolon Brad B Ferrando Ronald R Blackmore Craig C Schroeder Kurt K Rodriguez Luis A LA Hristopoulos Maria M Venook Rayna R Ashkenazi Avi A Desnoyers Luc R LR
PloS one 20120515 5
The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation of FGF-FGFR signaling may have important roles in tumor development and progression. The FGFR4-FGF19 signaling axis has been implicated in the development of hepatocellular carcinomas (HCCs) in mice, and potentially in humans. In this study, we demonstrate that FGFR4 is required for hepatocarci ...[more]