Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance.
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ABSTRACT:
SUBMITTER: Anastassopoulou CG
PROVIDER: S-EPMC3353024 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance.
Anastassopoulou Cleo G CG Ketas Thomas J TJ Sanders Rogier W RW Klasse Per Johan PJ Moore John P JP
Virology 20120419 2
A rare pathway of HIV-1 resistance to small molecule CCR5 inhibitors such as Vicriviroc (VCV) involves changes solely in the gp41 fusion peptide (FP). Here, we show that the G516V change is critical to VCV resistance in PBMC and TZM-bl cells, although it must be accompanied by either M518V or F519I to have a substantial impact. Modeling VCV inhibition data from the two cell types indicated that G516V allows both double mutants to use VCV-CCR5 complexes for entry. The model further identified F51 ...[more]
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