Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana.
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ABSTRACT:
SUBMITTER: Lin NH
PROVIDER: S-EPMC3353541 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
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Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana.
Lin Nina H NH Smeaton Laura M LM Giguel Françoise F Novitsky Vladimir V Moyo Sikhulile S Mitchell Rebecca M RM Makhema Joseph J Essex Myron M Lockman Shahin S Kuritzkes Daniel R DR
Journal of acquired immune deficiency syndromes (1999) 20110501 1
HIV-1 coreceptor use was determined using a phenotypic assay in plasma samples from treatment-naive women infected with subtype C virus who had CD4 cell counts below 200 cells/mm3. Of 148 women, 14.9% were infected with dual/mixed virus; the remainder had R5 virus. A greater proportion of women in the lowest CD4 cell count stratum had dual/mixed virus (P = 0.026); change in coreceptor use after antiretroviral therapy exposure was uncommon. CXCR4-using HIV-1 was less common in subtype C-infected ...[more]
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