Ontology highlight
ABSTRACT:
SUBMITTER: Cheung HW
PROVIDER: S-EPMC3353720 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Cheung Hihu Wing HW Du Jinyan J Boehm Jesse S JS He Frank F Weir Barbara A BA Wang Xiaoxing X Butaney Mohit M Sequist Lecia V LV Luo Biao B Engelman Jeffrey A JA Root David E DE Meyerson Matthew M Golub Todd R TR Jänne Pasi A PA Hahn William C WC
Cancer discovery 20111017 7
<h4>Unlabelled</h4>We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Overexpression of CRKL in immortalized human airway epithelial cells promoted anchorage-independent growth and tumorigenicity. Oncogenic CRKL activates the SOS1-RAS-RAF-ERK and SRC-C3 ...[more]