Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens.
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ABSTRACT:
SUBMITTER: Wang YC
PROVIDER: S-EPMC3354442 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Effects of zearalenone on IL-2, IL-6, and IFN-γ mRNA levels in the splenic lymphocytes of chickens.
Wang Y C YC Deng J L JL Xu S W SW Peng X X Zuo Z C ZC Cui H M HM Wang Y Y Ren Z H ZH
TheScientificWorldJournal 20120502
Zearalenone (ZEN) is an estrogenic mycotoxin produced by several Fusarium species, which can contaminate food and feed. These compounds elicit a wide spectrum of toxic effects, including the capacity to alter normal immune function. In this study, the in vitro effects of the treatment of ConA-stimulated splenic lymphocytes with ZEN (0-25 μg/mL) were examined. ZEN modulates the expression of IL-2, IL-6, and IFN-γ. The IL-2 levels were up to fourfold higher (P < 0.05) compared with the levels in t ...[more]
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