Ontology highlight
ABSTRACT:
SUBMITTER: Castonguay AC
PROVIDER: S-EPMC3355666 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Castonguay Alicia C AC Lasanajak Yi Y Song Xuezheng X Olson Linda J LJ Cummings Richard D RD Smith David F DF Dahms Nancy M NM
Glycobiology 20120227 7
The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays an essential role in the biogenesis of lysosomes by delivering newly synthesized lysosomal enzymes from the trans Golgi network to the endosomal system. The CI-MPR is expressed in most eukaryotes, with Saccharomyces cerevisiae and Caenorhabditis elegans being notable exceptions. Although the repertoire of glycans recognized by the bovine receptor has been studied extensively, little is known concerning the ligand-binding ...[more]