Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC3356442 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Zhao Zhen Z Oh Soohwan S Li Dapeng D Ni Duojiao D Pirooz Sara Dolatshahi SD Lee Joo-Hyung JH Yang Shunhua S Lee June-Yong JY Ghozalli Irene I Costanzo Vincenzo V Stark Jeremy M JM Liang Chengyu C
Developmental cell 20120426 5
Autophagy defects have recently been associated with chromosomal instability, a hallmark of human cancer. However, the functional specificity and mechanism of action of autophagy-related factors in genome stability remain elusive. Here we report that UVRAG, an autophagic tumor suppressor, plays a dual role in chromosomal stability, surprisingly independent of autophagy. We establish that UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end ...[more]