Ontology highlight
ABSTRACT:
SUBMITTER: Avasthi P
PROVIDER: S-EPMC3356477 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Avasthi Prachee P Marley Aaron A Lin Henry H Gregori-Puigjane Elisabet E Shoichet Brian K BK von Zastrow Mark M Marshall Wallace F WF
ACS chemical biology 20120308 5
Normal cilia length and motility are critical for proper cellular function. Prior studies of the regulation of ciliary structure and length have primarily focused on the intraflagellar transport machinery and motor proteins required for ciliary assembly and disassembly. However, several mutants with abnormal length flagella highlight the importance of signaling proteins as well. In this study, an unbiased chemical screen was performed to uncover signaling pathways that are critical for ciliogene ...[more]