Ontology highlight
ABSTRACT:
SUBMITTER: Cao Y
PROVIDER: S-EPMC3356620 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cao Yan Y Pahlberg Johan J Sarria Ignacio I Kamasawa Naomi N Sampath Alapakkam P AP Martemyanov Kirill A KA
Proceedings of the National Academy of Sciences of the United States of America 20120430 20
The time course of signaling via heterotrimeric G proteins is controlled through their activation by G-protein coupled receptors and deactivation through the action of GTPase accelerating proteins (GAPs). Here we identify RGS7 and RGS11 as the key GAPs in the mGluR6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses. We showed using electroretinography and single cell recordings that the elimination of RGS7 did not influence dark-adapted li ...[more]