Ontology highlight
ABSTRACT:
SUBMITTER: Kaur S
PROVIDER: S-EPMC3356630 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Kaur Surinder S Sassano Antonella A Majchrzak-Kita Beata B Baker Darren P DP Su Bing B Fish Eleanor N EN Platanias Leonidas C LC
Proceedings of the National Academy of Sciences of the United States of America 20120501 20
IFNs transduce signals by binding to cell surface receptors and activating cellular pathways and regulatory networks that control transcription of IFN-stimulated genes (ISGs) and mRNA translation, leading to generation of protein products that mediate biological responses. Previous studies have shown that type I IFN receptor-engaged pathways downstream of AKT and mammalian target of rapamycin complex (mTORC) 1 play important roles in mRNA translation of ISGs and the generation of IFN responses, ...[more]