Ontology highlight
ABSTRACT:
SUBMITTER: Sanderson NS
PROVIDER: S-EPMC3356634 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Sanderson Nicholas Stephen Rennie NS Puntel Mariana M Kroeger Kurt M KM Bondale Niyati S NS Swerdlow Mark M Iranmanesh Niloufar N Yagita Hideo H Ibrahim Ahmed A Castro Maria G MG Lowenstein Pedro R PR
Proceedings of the National Academy of Sciences of the United States of America 20120430 20
Following antigen recognition on target cells, effector T cells establish immunological synapses and secrete cytokines. It is thought that T cells secrete cytokines in one of two modes: either synaptically (i.e., toward antigenic target cells) or multidirectionally, affecting a wider population of cells. This paradigm predicts that synaptically secreted cytokines such as IFN-γ will preferentially signal to antigenic target cells contacted by the T cell through an immunological synapse. Despite i ...[more]