Ontology highlight
ABSTRACT:
SUBMITTER: Morton D
PROVIDER: S-EPMC3357189 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Morton Daniel D Dick Allison R AR Ghosh Debashis D Davies Huw M L HM
Chemical communications (Cambridge, England) 20120509 47
The preparation and reactivity of steroidal vinyldiazo compounds is reported, providing a convenient, substituent tolerant, chemo- and stereoselective entry into 4- and 6-substituted androgen analogues from a common precursor. Under dirhodium catalysis, O-H insertion occurs at the carbenoid site, leading to 4-substituted steroids, but under silver catalysis, O-H insertion occurs at the vinylogous position, leading to 6-substituted steroids. ...[more]