Ontology highlight
ABSTRACT:
SUBMITTER: Wong AL
PROVIDER: S-EPMC3357513 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wong Andrea L A AL Lee Soo-Chin SC
International journal of breast cancer 20120509
HER2-positive breast cancers have poorer prognosis and are prime candidates for molecular-targeted therapy because they are driven by the unique mechanism of HER2 oncogene addiction. While anti-HER2 agents such as trastuzumab and lapatinib are integral to the treatment of HER2-positive breast cancer, intrinsic and secondary resistance pose a significant challenge, underscoring the need to develop novel anti-HER2 therapies. In recent years, an array of promising and novel anti-HER2 therapeutic ag ...[more]