Ontology highlight
ABSTRACT:
SUBMITTER: Malek M
PROVIDER: S-EPMC3358017 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Malek M M Guillaumot P P Huber A-L AL Lebeau J J Pétrilli V V Kfoury A A Mikaelian I I Renno T T Manié S N SN
Cell death & disease 20120419
Lysosomal regulation is a poorly understood mechanism that is central to degradation and recycling processes. Here we report that LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and mTOR activator 1) downregulation affects lysosomal activation, through mechanisms that are not solely due to mTORC1 inhibition. LAMTOR1 depletion strongly increases lysosomal structures that display a scattered intracellular positioning. Despite their altered positioning, those dispersed structures remain overall fun ...[more]