Dataset Information

Concomitant pulmonary tuberculosis in hospitalized healthcare-associated pneumonia in a tuberculosis endemic area: a multi-center retrospective study.

ABSTRACT:

Background

In tuberculosis (TB) endemic areas, Mycobacterium tuberculosis is an important but easily misdiagnosed pathogen in community-acquired pneumonia (CAP). However, the occurrence of concomitant pulmonary tuberculosis (PTB) in hospitalized healthcare-associated pneumonia (HCAP) has never been investigated.

Methods and findings

Seven hundred and one hospitalized HCAP and 934 hospitalized CAP patients from six medical centers in Taiwan were included in this nationwide retrospective study. Concomitant PTB was defined as active PTB diagnosed within 60 days of admission due to HCAP or CAP. The predictors for concomitant PTB and the impact of PTB on the outcomes of pneumonia were investigated. Among the enrolled subjects, 21/701 (3%) of the HCAP patients and 25/934 (2.7%) of the CAP patients were documented to have concomitant PTB. In multivariate analysis, a history of previous anti-TB treatment (OR?=?5.84, 95% CI: 2.29-20.37 in HCAP; OR?=?3.33, 95% CI: 1.09-10.22 in CAP) and escalated pneumonia severity index (PSI) scores (OR?=?1.014, 95% CI: 1.002-1.026, in HCAP; OR?=?1.013, 95% CI: 1.001-1.026, in CAP) were independent predictors for concomitant PTB in both CAP and HCAP patients. Regarding treatment outcomes, HCAP patients with concomitant PTB were associated with more acute respiratory failure within 48 hours of admission (47.6% vs. 22.6%, p?=?0.008), higher intensive care unit admission rate (61.9% vs. 35.7%, p?=?0.014), longer hospitalization (39.6±34.1 vs. 23.7±27 days, p?=?0.009), and higher in-hospital mortality (47.6% vs. 26.3%, p?=?0.03) than those without concomitant PTB. Exposure to certain groups of antibiotics for the treatment of pneumonia was not associated with the occurrence of concomitant PTB.

Conclusions

In HCAP patients, the occurrence of concomitant PTB is comparable with that in CAP patients and associated with higher PSI scores, more acute respiratory failure, and higher in-hospital mortality.

SUBMITTER: Feng JY

PROVIDER: S-EPMC3358294 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

Concomitant pulmonary tuberculosis in hospitalized healthcare-associated pneumonia in a tuberculosis endemic area: a multi-center retrospective study.

Feng Jia-Yih JY Fang Wen-Feng WF Wu Chieh-Liang CL Yu Chong-Jen CJ Lin Meng-Chih MC Ku Shih-Chi SC Chen Yu-Chun YC Chen Chang-Wen CW Tu Chih-Yen CY Su Wei-Juin WJ Yang Kuang-Yao KY

PloS one 20120522 5

<h4>Background</h4>In tuberculosis (TB) endemic areas, Mycobacterium tuberculosis is an important but easily misdiagnosed pathogen in community-acquired pneumonia (CAP). However, the occurrence of concomitant pulmonary tuberculosis (PTB) in hospitalized healthcare-associated pneumonia (HCAP) has never been investigated.<h4>Methods and findings</h4>Seven hundred and one hospitalized HCAP and 934 hospitalized CAP patients from six medical centers in Taiwan were included in this nationwide retrospe ...[more]

PMID: 22629334

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Dataset Information

Concomitant pulmonary tuberculosis in hospitalized healthcare-associated pneumonia in a tuberculosis endemic area: a multi-center retrospective study.

Background

Methods and findings

Conclusions

Publications

Concomitant pulmonary tuberculosis in hospitalized healthcare-associated pneumonia in a tuberculosis endemic area: a multi-center retrospective study.

Similar Datasets

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