Ontology highlight
ABSTRACT:
SUBMITTER: Shah A
PROVIDER: S-EPMC3358364 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Shah Ankur A Seedhouse Claire C
Indian journal of clinical biochemistry : IJCB 20120324 2
The purpose of this study is to find out the frequency of TP53 mutations in acute myeloid leukemia (AML) patients and correlate sensitivity of drug response with TP53 mutations. In AML more than 90 % of cases comprise of wild type TP53. 94.2 % of TP53 mutations are found within exon 5-8 of which 73 % are point mutations. TP53 mutations were analysed with high resolution melting curve analysis. We analysed 106 AML samples of which we found nine mutations which represents 8.5 % mutation rate and f ...[more]