Ontology highlight
ABSTRACT:
SUBMITTER: Weidner C
PROVIDER: S-EPMC3358853 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Weidner Christopher C de Groot Jens C JC Prasad Aman A Freiwald Anja A Quedenau Claudia C Kliem Magdalena M Witzke Annabell A Kodelja Vitam V Han Chung-Ting CT Giegold Sascha S Baumann Matthias M Klebl Bert B Siems Karsten K Müller-Kuhrt Lutz L Schürmann Annette A Schüler Rita R Pfeiffer Andreas F H AF Schroeder Frank C FC Büssow Konrad K Sauer Sascha S
Proceedings of the National Academy of Sciences of the United States of America 20120416 19
Given worldwide increases in the incidence of obesity and type 2 diabetes, new strategies for preventing and treating metabolic diseases are needed. The nuclear receptor PPARγ (peroxisome proliferator-activated receptor gamma) plays a central role in lipid and glucose metabolism; however, current PPARγ-targeting drugs are characterized by undesirable side effects. Natural products from edible biomaterial provide a structurally diverse resource to alleviate complex disorders via tailored nutritio ...[more]