Ontology highlight
ABSTRACT:
SUBMITTER: Tunes-da-Silva G
PROVIDER: S-EPMC3359021 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Computational statistics & data analysis 20110101 1
We consider the problem of dichotomizing a continuous covariate when performing a regression analysis based on a generalized estimation approach. The problem involves estimation of the cutpoint for the covariate and testing the hypothesis that the binary covariate constructed from the continuous covariate has a significant impact on the outcome. Due to the multiple testing used to find the optimal cutpoint, we need to make an adjustment to the usual significance test to preserve the type-I error ...[more]