Ontology highlight
ABSTRACT:
SUBMITTER: Das K
PROVIDER: S-EPMC3359132 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Das Kalyan K Martinez Sergio E SE Bauman Joseph D JD Arnold Eddy E
Nature structural & molecular biology 20120122 2
Combinations of nucleoside and non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT) are widely used in anti-AIDS therapies. Five NNRTIs, including nevirapine, are clinical drugs; however, the molecular mechanism of inhibition by NNRTIs is not clear. We determined the crystal structures of RT-DNA-nevirapine, RT-DNA, and RT-DNA-AZT-triphosphate complexes at 2.85-, 2.70- and 2.80-Å resolution, respectively. The RT-DNA complex in the crystal could bind nevirapine or AZT-triphosphat ...[more]